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Reference type: Journal
Authors: Cederfur J, Pei YX, Meng ZH, Kempe M
Article Title: Synthesis and screening of a molecularly imprinted polymer library targeted for penicillin G.
Publication date: 2003
Journal: Journal of Combinatorial Chemistry
Volume: 5
Issue: (1)
Page numbers: 67-72.
DOI: 10.1021/cc020051n

Abstract: A library of molecularly imprinted polymers (MIPs) was synthesized by radical bulk polymerization using the beta- lactam antibiotic penicillin G as the template. Diversity of the library was obtained by combining various functionalized monomers and cross-linkers and by varying the stoichiometry and the concentration of the components in the prepolymerization mixtures. The library was screened for selectivity to penicillin G by a radioligand binding assay and was compared to a corresponding control library. The best MIP candidate, showing the highest selectivity for penicillin G, was prepared from methacrylic acid and trimethylolpropane trimethacrylate as the functionalized monomer and cross-linker, respectively. Cross-reactivity studies with other beta-lactam antibiotics showed a low cross-reactivity of penicillin V (15%), ampicillin (16%), and amoxicillin (19%). Nafcillin and oxacillin showed less cross-reactivity (<1%). Cross-reaction with a cephalosporin antibiotic (cephapirin) and structurally nonrelated antibiotics (chloramphenicol, tetracycline, dapsone, and erythromycin) was less than 0.01%


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