Alternatively for mipdatabase quick searches go here

Custom Search

Abstract: Herein an approach to prepare molecularly imprinted polymer nanoparticles (nanoMIPs) with specific binding affinity for antibodies is reported. The process relied on the covalent immobilization of the template (whole immunoglobulin G (IgG), Fc domain of human IgG and peptide epitope) onto the surface of a solid support, polymerization and affinity separation of nanoMIPs. The binding between nanoMIPs and their corresponding templates was analyzed and evaluated as being in sub-nanomolar and nano-molar range. The nanoMIPs prepared for Fc domain and epitope demonstrated a specific recognition of both human and goat IgGs, therefore they could be considered as a synthetic analogue of protein A and benefit from its intrinsic stability, short time and low cost of preparation
Template and target information: antibodies, peptide, epitope, immunoglobulin G, IgG, Fc domain of human IgG
Author keywords: molecular imprinting polymers, nanoparticles, affinity chromatography, solid-phase synthesis, antibodies, Protein epitope