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Reference type: Journal
Authors: Yang KG, Li SW, Liu LK, Chen YW, Zhou W, Pei JQ, Liang Z, Zhang LH, Zhang YK
Article Title: Epitope Imprinting Technology: Progress, Applications, and Perspectives toward Artificial Antibodies.
Publication date: 2019
Journal: Advanced Materials
Volume: 31
Issue: (50)
Article Number: 1902048.
DOI: 10.1002/adma.201902048

Abstract: Epitope imprinting is a promising tool to generate antibody-like specific recognition sites. Recently, because of the ease of obtaining templates, the flexibility in selecting monomers, their resistance to harsh environments, and the high specificity toward targets, epitope-imprinted materials have attracted much attention in various fields, such as bioanalysis, clinical therapy, and pharmacy. Here, the discussion is focused on the current representative epitope imprinting technologies, including epitope bulk imprinting and epitope surface imprinting. Moreover, the application of epitope-imprinted materials to the recognition of peptides, proteins, and cells is reviewed. Finally, the remaining challenges arising from the intrinsic properties of epitope imprinting are discussed, and future development in the field is prospected
Template and target information: review - MIPs imprinted with epitopes
Author keywords: artificial antibodies, epitopes, molecular imprinting, molecular recognition


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