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Authors: Cennamo N, Maniglio D, Tatti R, Zeni L, Bossi AM
Article Title: Deformable molecularly imprinted nanogels permit sensitivity-gain in plasmonic sensing.
Publication date: 2020
Journal: Biosensors and Bioelectronics
Volume: 156
Article Number: 112126.
DOI: 10.1016/j.bios.2020.112126
Alternative URL: https://www.sciencedirect.com/science/article/pii/S0956566320301238
Abstract: Soft molecularly imprinted nanogels (nanoMIPs), selective for human transferrin (HTR), were prepared via a template assisted synthesis. Owing to their soft matter, the nanoMIPs were observed to deform at binding to HTR: while no relevant changes were observed in the hydrodynamic sizes of HTR-free compared to HTR-loaded nanoMIPs, the HTR binding resulted in a significant increment of the nanoMIP stiffness, with the mean Young's modulus measured by AFM passing from 17 ± 6 kPa to 56 ± 18 kPa. When coupled to a plastic optical fibre (POF) plasmonic platform, the analyte-induced nanoMIP-deformations amplified the resonance shift, enabling to attain ultra-low sensitivities (LOD = 1.2 fM; linear dynamic range of concentrations from 1.2 fM to 1.8 pM). Therefore, soft molecularly imprinted nanogels that obey to analyte-induced deformation stand as a novel class of sensitivity-gain structures for plasmonic sensing
Template and target information: human transferrin, HTR, transferrin
Author keywords: Molecularly imprinted polymers, Responsive nanogel, plastic optical fibres, surface plasmon resonance, Active plasmonics
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