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Abstract: Tetracycline (TC) plays a considerable role in the fight against microbial diseases. However, over-use of TC can produce serious harmful effects on humans and even may lead to drug tolerance. Herein, we developed a novel sensitive fluorescent nanosensor based on the encapsulation of magnesium and nitrogen co-doped carbon dots (Mg,N-CDs) into molecularly imprinted polymer (Mg,N-CDs@MIP), which can be utilized for the specific recognition and ultrasensitive detection of TC in animal-derived foods. The high luminescent carbon dots with a maximum emission wavelength of 455 nm under 350 nm excitation and a 33.05 % quantum yield were firstly synthesized using the Mg/N co-doped fluorescence-enhanced strategy, and the introduction of Mg,N-CDs as a signal tag can significantly enhance the sensitivity of fluorescent sensor. Then, via a facile and efficient one-pot reaction, the Mg,N-CDs@MIP was obtained. The resulting Mg,N-CDs@MIP not only displayed superior optical stability and good reusability, but also exhibited higher specificity and selectivity to TC compared with non-imprinted polymer (Mg,N-CDs@NIP) and Mg,N-CDs. The developed sensor was applied for determination of TC, and its fluorescence intensity was linearly quenched with the increasing concentration of TC from 5-100 ng mL-1 with a detection limit of 0.79 ng mL-1. Additionally, the proposed sensor was utilized for trace analysis of TC in complex foods, and the satisfactory results obtained were consistent with those obtained by HPLC
Template and target information: tetracycline, TC
Author keywords: Mg, N co-doped carbon dots, Tetracycline, Molecularly imprinted polymers, Animal-derived foods