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Abstract: A platform equipped with a well-designed synthetic interface, as a universal sensor, is required to detect highly selective and sensitive anticancer drugs in complex matrices of different biological samples. In this study, we developed a novel electrochemical sensor based on the combination of molecularly imprinted method with the 3D-framework UiO-66-NH2 as excellent target molecule recognizer on the surface of a glassy carbon electrode modified with carbon quantum dots incorporated hexagonal boron nitride nanosheets (CQDs@HBNNS/UiO-66-NH2 /MIP/GCE) for ultraselective detection of trace levels of Oxaliplatin (OXA) as an anticancer drug. The increased efficiency and sensitivity of the proposed MIP sensor was obtained due to the use of UiO-66-NH2 with high porosity structure which effectively increased the number of binding sites and specific surface area as well as CQDs@HBNNS nanocomposite (CQDs@HBNNS-NCs) with ideal electric conductivity and synergistic effects to facilitate the electron transfer process. During MIP preparation, optimal conditions were achieved by using experimental design, based on a standard orthogonal array, and different electrodes were characterized by scanning electron microscopy and cyclic voltammetry. Electrochemical responses of imprinted sensor displayed two dynamic linear ranges from 1.0 to 20.0 nM and 20.0 to 250.0 nM with a detection limit of 0.37 nM. In addition, superior anti-interfering ability of the designed MIP sensor toward OXA detection in the presence of interferents at high concentration especially other Pt-based anticancer drugs as well as reproducibility and stability of it proved that the CQDs@HBNNS/UiO-66-NH2 /MIP/GCE could be extensively applied in the clinical therapeutic drug monitoring
Template and target information: oxaliplatin, OXA
Author keywords: Oxaliplatin, molecularly imprinted polymer, Metal-organic framework, Carbon quantum dots, Hexagonal boron nitride nanosheets