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Abstract: This study introduces an innovative procedure for the development of a molecularly imprinted electrochemical sensor for ultra-sensitive and selective detection of patulin. Firstly, the surface of a glassy carbon electrode (GCE) was decorated by nitrogen doped graphene quantum dots (N-GQDs) and AuNPs-functionalized Cu-metal organic framework (Au@Cu-MOF) and then a layer of molecularly imprinted polymer (MIP) was grown on Au@Cu-MOF/N-GQDs/GCE by electropolymerization. Electrochemical techniques were used to characterize and study the electrochemical behavior of the MIP/Au@Cu-MOF/N-GQDs/GCE, which exhibited a stable reference peak of Au@Cu-MOF at -0.11 V after elution of patulin molecules. This peak current density decreased with rebinding of patulin molecules therefore it was considered as indicator signal. The designed MIP sensor presented a wide linear range from 0.001 to 70.0 ng mL-1, and a low detection limit (0.0007 ng mL-1). This newly developed method based on the synergistic effects of N-GQDs and Au@Cu-MOF combined with MIP technique offered outstanding selectivity, sensitivity, stability, and reproducibility. The good accuracy (recovery%, 97.6-99.4) and high precision (RSD%, 1.23-4.61) of this sensing system for analysis of apple juices proved the high potential of it for rapid and low cost determination of patulin compared to chromatographic methods
Template and target information: patulin
Author keywords: patulin, molecularly imprinted polymer, Metal-organic framework, Nitrogen doped graphene quantum dots, Electrochemical sensor