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Abstract: Molecular imprinted polymer (MIP) has been employed for electrochemical sensor preparation with good selectivity. However, to restrict the non-specific adsorption, the conductivity of MIP is usually unsatisfying, which limits its sensitivity for template detection. To achieve both of selectivity and sensitivity, a MIP electrochemical sensor was designed and fabricated by the electropolymerization of pyrrole in the presence of aloe-emodin (AE, template molecule) on carbon nanoparticles modified electrode in this work. Thionine (TH), being added in solution in advance, played double roles for AE recognition and detection. As an analogue of AE, TH was adsorbed into imprinted cavities and then was replaced by AE, indicating the good selectivity of the sensor. This replacement of TH by AE was also demonstrated by the result of computational simulation. As an electro-active probe, the peak current of TH decreased and peak current of AE increased based on the replacement of TH by AE. A current ratiometric signal defined as |Δ iAE|/|Δ iTH| was used for AE sensitive detection. Thus, the replacements of TH by AE demonstrated that the sensor possessed high sensitivity and good selectivity. A linear range of 1.0 × 10-7 - 1.0 × 10-4 mol/L for AE detection was obtained with a limit of detection of 7.5 × 10-8 mol/L. And the sensor has been applied to analyze AE in real samples with satisfactory results. The simple, smart, and effective strategy presented in this work can be further used to prepare electrochemical sensors for other compounds selective recognition and sensitive detection
Template and target information: thionine, TH, aloe-emodin, AE
Author keywords: Ratiometric electrochemical sensor, molecularly imprinted polymer, Thionine, Double roles, Aloe-emodin