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Authors: Yang XL, Liu H, Ji YT, Xu S, Xia CM, Zhang RL, Zhang CG, Miao ZC
Article Title: A molecularly imprinted biosensor based on water-compatible and electroactive polymeric nanoparticles for lysozyme detection.
Publication date: 2022
Journal: Talanta
Volume: 236
Article Number: 122891.
DOI: 10.1016/j.talanta.2021.122891
Alternative URL: https://www.sciencedirect.com/science/article/pii/S0039914021008122
Abstract: A molecularly imprinted biosensor for lysozyme based on the polymer nanoparticles self-assembled from water-soluble and electroactive poly (γ-glutamic acid) modified with 3-aminothiophene copolymer were prepared. The water-soluble copolymer made imprinting of lysozyme in aqueous solution possible and thus facilitated improvement of the activity of LYS. Subsequent electro-polymerization not only locked the recognition site between copolymer and lysozyme but also created a conductive polymer network, which can enhance the electron transfer rate and increase the conductivity of the film. The prepared molecularly imprinted biosensor exhibited a wide linear range from 1 × 10-10 to 1 × 10-5 mg mL-1, and satisfactory selectivity, stability, repeatability for lysozyme detection
Template and target information: protein, lysozyme, LYS
Author keywords: Molecularly imprinted biosensor, Self-assembled nanoparticles, Lysozyme detection
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