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Abstract: Molecularly imprinted polymers (MIPs) with specific selective recognition have shown excellent performance in the rapid and efficient separation and enrichment of targets in complex systems. Unfortunately, it is not suitable for thermosensitive substances with biological functions. To this end, an imine-linked MIPs with covalent organic frameworks and magnetic nanoparticles was developed by using a room temperature synthesis strategy for the purification of Cyaninin-3-O-glucoside (C3G) from black chokeberry. The prepared material recognized C3G through π-π interaction, assisted by hydrogen bond, and will not be disturbed by water environment. The adsorption capacity and equilibrium binding constant were 86.92 mg g-1 and 1.46 L mg-1, respectively. Based on this special structure, it can also act as a "protective umbrella" and improve the stability of C3G. Furthermore, it exhibited high selectivity compared with dummy template imprinting technique. After purification, the purity of C3G was obviously improved (from 11.96% to 84.72%). This work provided a new strategy for the selective separation of anthocyanin and a method to develop MIPs for thermosensitive substances
Template and target information: cyaninin-3-O-glucoside, C3G
Author keywords: Molecularly imprinted polymers, Covalent organic frameworks, Cyanidin-3-O-Glucoside, Room temperature synthesis, Stabilization technology