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Reference type: Journal
Authors: Chen GH, Guan ZB, Chen CT, Fu LT, Sundaresan V, Arnold FH
Article Title: A glucose-sensing polymer.
Publication date: 1997
Journal: Nature Biotechnology
Volume: 15
Issue: (4)
Page numbers: 354-357.
DOI: 10.1038/nbt0497-354

Abstract: We have prepared a robust polymer that can be used to measure glucose concentrations in complex biological media. At alkaline pH, the metal-complexing polymer binds glucose and instantly releases protons in proportion to the glucose concentration over a clinically relevant range (0 to 25 mM). The inexpensive polymer is sufficiently selective to provide an easily measurable response to glucose in porcine plasma. The polymer's ability to function at nonphysiological pH (at which the buffer capacity of biological samples is small) makes it possible to design simple and inexpensive sensing devices based on measurement of changes in proton concentration

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