MIPdatabase
Authors: Xu ZY, Jiang XX, Liu SP, Yang MH
Article Title: Sensitive and selective molecularly imprinted electrochemical sensor based on multi-walled carbon nanotubes for doxycycline hyclate determination.
Publication date: 2020
Journal: Chinese Chemical Letters
Volume: 31
Issue: (1)
Page numbers: 185-188.
DOI: 10.1016/j.cclet.2019.04.026
Alternative URL: https://www.sciencedirect.com/science/article/pii/S1001841719301962
Abstract: An electrochemical sensor for doxycycline hyclate (DC) detection with high sensitivity and good selectivity is reported. The sensor was fabricated by electro-polymerization of molecularly imprinted polymers (MIPs) in the presence of DC onto multi-walled carbon nanotubes modified glassy carbon electrode (MWCNTs/GCE). The MWCNTs can significantly increase the current response of the sensor, leading to enhanced sensitivity. The MIPs provide selective recognition sites for DC detection. The experimental parameters, such as the polymer monomer concentration, supporting electrolyte pH, the time for electro-polymerization and the incubation time of the sensor with DC were optimized. Under optimized experimental conditions, the sensor displayed a linear range of 0.05 μmol/L - 0.5 μmol/L towards DC detection, with the detection limit of 1.3 × 10-2 μmol/L. The sensor was successfully applied for recovery test of DC in human serum samples
Template and target information: doxycycline hyclate, DC
Author keywords: Electrochemical sensor, Doxcycline hyclate, Molecularly imprinted polymers, Multi-walled carbon nanotubes, electro-polymerization
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