MIPdatabase
Authors: Amlashi HS, Daryasari AP, Soleimani M
Article Title: Molecularly imprinted polymer solid phase extraction followed by high-performance liquid chromatography as an efficient and sensitive technique for determination of meropenem in human plasma and urine.
Publication date: 2019
Journal: South African Journal of Chemistry
Volume: 72
Issue: (1)
Page numbers: 32-39.
DOI: 10.17159/0379-4350/2019/v72a5
Alternative URL: http://www.scielo.org.za/scielo.php?script=sci_abstract&pid=S0379-43502019000100008&lng=en&nrm=iso&tlng=en
Abstract: A new and selective sorbent for molecularly imprinted polymer solid-phase extraction (MIP-SPE) was prepared to extract meropenem from plasma and urine samples. The extracted analyte was analyzed by high-performance liquid chromatography (HPLC) coupled with photodiode array detection. Methacrylic acid (MAA) as functional monomer, ethylene glycol dimethacrylate (EGDMA) as cross-linker, azobisisobutyronitrile (AIBN) as an initiator and meropenem as a template molecule were used for the MIP preparation. Imprinted meropenem molecule was removed from the polymeric structure using acetonitrile in water (1:9,v/v), as the eluent solvent. Under the optimized conditions, the limit of detection (LOD) and limit of quantification (LOQ) were 35 and 120 μg L-1 , respectively. The developed MIP-SPE method demonstrates that it could be applied for the determination of meropenem in plasma and urine samples
Template and target information: meropenem
Author keywords: molecularly imprinted polymer, Solid-phase extraction, meropenem, human urine and plasma, high-performance liquid chromatography
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