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Reference type: Journal
Authors: Chen W, Liu F, Li KA, Yang YH, Tong SY
Article Title: A hydrochlorothiazide-imprinted polymer.
Publication date: 2000
Journal: Analytical Letters
Volume: 33
Page numbers: 809-818.
DOI: 10.1080/00032710008543090
Alternative URL: http://www.informaworld.com/10.1080/00032710008543090

Abstract: Hydrochlorothiazide (HCT) is a medicine commonly used as a diuretic. A series of HCT-imprinted polymers were prepared using 4- vinylpyridine or methacrylic acid or none as a functional monomer. Liquid chromatographic analysis using the polymers as a stationary phase showed that 4-vinylpyridine was suitable for synthesizing HCT- selective polymers. It appeared that the sulfonamide groups on HCT molecule could interact with 4-vinylpyridine through ionic interaction, and thus could be used as a functional group for molecular imprinting. The prepared HCT-specific polymers should have applications for clinical analysis of HCT

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