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Abstract: The nanoparticles of carbon quantum dots embedded silica molecular imprinted polymer (CQDs-SiO2@MIP) were utilized as novel, sensitive, repeatable, and reproducible enantioselective fluorescent nanoprobes for enantioselective quantification of naproxen molecules. The combination of MIP and CQDs was the basis for selectivity enhancement in chiral recognition of naproxen enantiomers due to template selectivity of the synthesized CQDs-SiO2@MIP. Introducing naproxen molecules to the system, selectively induced a considerable quenching of the fluorescence of the CQDs-SiO2@MIP with an efficient distinction between S- and R-enantiomers. The method showed a wide linear working range of 0.5-35.0 μM for S-naproxen and 0.5-30.0 μM for R-naproxen. However, the calibration sensitivity for S-naproxen was estimated at 2.0-fold higher than R-naproxen. Also, the detection limits were calculated to be 0.20 and 0.37 μM for S- and R-naproxen, respectively. The relative standard deviations (RSD %) as an index for repeatability and reproducibility of the developed method were estimated to be 1.4% and 4.0% for intra-day and inter-day assays, respectively
Template and target information: naproxen
Author keywords: Carbon quantum dots, molecular imprinted polymer, naproxen, chiral recognition, Fluorescent nanoprobe