MIPdatabase
Authors: Duan LK, Zhao Y
Article Title: Molecularly imprinted micelles for fluorescent sensing of nonsteroidal anti-inflammatory drugs (NSAIDs).
Publication date: 2021
Journal: Reactive and Functional Polymers
Volume: 158
Article Number: 104759.
DOI: 10.1016/j.reactfunctpolym.2020.104759
Alternative URL: https://www.sciencedirect.com/science/article/pii/S1381514820306441
Abstract: Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used over-the-counter drugs and their uncontrolled disposal is a significant environmental concern. Although their fluorescent sensing is a desirable method of detection for its sensitivity and simplicity, the structural similarity of the drugs makes the design of selective sensors highly challenging. A thiourea-based fluorescent functional monomer was identified in this work to enable highly efficient synthesis of molecularly imprinted nanoparticle (MINP) sensors for NSAIDs such as Indomethacin or Tolmetin. Micromolar binding affinities were obtained in aqueous solution, with binding selectivities comparable to those reported for polyclonal antibodies. The detection limit was ~50 ng/mL in aqueous solution, and common carboxylic acids such as acetic acid, benzoic acid, and citric acid showed negligible interference
Template and target information: nonsteroidal anti-inflammatory drugs, NSAIDs, indomethacin, tolmetin
Author keywords: fluorescent sensing, molecular imprinting, binding, NSAID, Micelle
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