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Abstract: Molecularly imprinted allyl trimethoxysilane -grafted- graphene oxide/gold nano particle co polymerised with -allyl amine (AA) /2-aminoethyl methacrylate hydrochloride (AEMA) polymer (GO/AuNP-g-ATMS-co-AEMA/AA) was synthesised by bulk imprinting method. The synthesised product was tested for sensing and quantifying methylmalonic acid (MMA) in blood samples in selective manner. Electrochemical studies performed with the developed sensor. The effective pH for the response of the sensor material was found to be 7.4. The response time, limit of detection (LOD) and limit of quantification (LOQ) of the electrode was found to be ~2 min, 0.2095 μM and 0.2935 μM respectively. The constructed sensor exhibits great selectivity and is useful for the rapid determination of MMA in human serum. The designed electrode is long lasting, reproducible and no pre-treatment of biological samples required during clinical analysis which makes it advantageous. The feasibility of the developed sensor was ensured by comparing it with the HP GC/MSD method practiced in diagnostic laboratory (correlation coefficient of 0.967). These results clearly indicate that the sensor developed through molecularly imprinting technique is valid for real sample analysis
Template and target information: methylmalonic acid, MMA
Author keywords: Graphene oxide, gold nanoparticles, Allyl trimethoxysilane molecular imprinting, Methylmalonic acid, electrochemical sensing