MIPs logo MIPdatabase      Use this space
Custom Search
Reference type: Journal
Authors: de Brito TP, de Aguiar DVA, Pereira I, Vaz BG
Article Title: Determining Methamphetamine in Urine by Molecularly Imprinted Polymer Assisted Paper Spray Ionization Mass Spectrometry.
Publication date: 2021
Journal: Journal of the Brazilian Chemical Society
Volume: 32
Issue: (2)
Page numbers: 269-276.
DOI: 10.21577/0103-5053.20200177
Alternative URL: https://www.scielo.br/j/jbchs/a/X78b7hRGVX7xy5fQSmp74vt/?lang=en

Abstract: The usefulness of molecularly imprinted polymer assisted paper spray ionization mass spectrometry (MIP-PSI-MS) for the determination of methamphetamine in urine has been demonstrated. MIP-PSI-MS is a method in which a MIP is synthesized on the surface of a paper, producing a chemically selective paper surface with molecular recognition sites for a target analyte. The analyte is extracted by the MIP substrate, which is posteriorly used for conventional PSI-MS analysis. As methamphetamine is one of the most widely used drugs of abuse in the world, it was selected to be studied in synthetic urine by the MIP-PSI-MS method. Methamphetamine was detected at higher ion signals compared to other different drugs, such as lysergic acid diethylamide (LSD) and cocaine, suggesting that MIP-PSI-MS has a chemical affinity for methamphetamine. In experiments to validate the method, a linear calibration curve was achieved with R-squared (R2) > 0.99. Limit of detection (LOD) and limit of quantification (LOQ) were determined to be 0.8 and 2.8 μg L-1, respectively. Precision (relative standard deviation) and accuracy (relative error) were less than 10%, and the recoveries were close to 100%. The matrix effect was below 10%. These data demonstrate the possibility of using MIP-PSI-MS as an analytical tool for a specific/selective analysis of methamphetamine in forensic sciences.
Template and target information: methamphetamine
Author keywords: Ambient mass spectrometry, Paper spray ionization, molecularly imprinted polymer, Methamphetamine

  Plutonium periodic table mug  Scientist peptide mug  I shop perodically customisable tote bag

Molecules Special Issue call      Appeal for information


Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.

Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:

Mickey Mouse 90th Anniversary banner