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Abstract: In this research project, a selective and sensitive sensor was electrochemically designed to measure metformin hydrochloride (MET) based on molecularly imprinted polymer (MIP). To prepare the sensor, the polypyrrole was electrochemically synthesized on a pencil graphite electrode (PGE), which modified with silver nanoparticles (AgNPs). Cyclic voltammetry and differential pulse voltammetry techniques were performed to fabricate the sensor and quantitative measurements, respectively. To select the functional monomers, a computational method was used. Some critical factors controlling the performance of the MIP-AgNPs-PGE were optimized using Plackett-Burman design and central composite design methods. Under optimal conditions, a calibration curve was obtained in the range 0.1-1000 μM with a limit of detection of 6.8 nM (S/N = 3, n = 3) and limit of quantitation of 22.8 nM (S/N = 10, n = 3). RSD of 3.9 and 4.1% were obtained for repeatability and reproducibility of the system, respectively. Furthermore, the modified sensor was successfully used for the determination of MET concentration in some real samples
Template and target information: metformin hydrochloride, MET