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Abstract: A magnetic molecularly imprinted biopolymer with hydrophilic properties was synthesized as eco-friendly biosorbent for the selective extraction of cardiovascular drugs from human urine samples. The sorbent preparation was carried out by introducing a green reaction based on biopolymerization route. In order to carry out the dispersive solid phase extraction (DSPE), magnetic sorbent was added to real sample. After extraction, the sorbent was separated from the bulk solution through a magnet. The separated sorbent washed with 5 mL of water and after that eluted by 8 mL of ethanol as desorption solvent to release the analyte. After sorbent elution, the extracted phase spiked with (40%, w/v) of rhaminolipid biosurfactant in order to emulsion formation. Subsequently, the analyte was efficiently extracted into resulting emulsion on the basis of the hydrophilic and hydrophobic interactions and was analyzed by liquid chromatography. Rhaminolipid biosurfactants were used as an extraction solvent due to biodegradability and the special molecular structure with hydrophilic and hydrophobic portions. Several influential factors including the type and volume of desorption solvents, type of washing solvent, amount of biosurfactant, pH and amount of sorbent were investigated and optimized. Acceptable enrichment factors (350, 360) and high squared regression coefficients r2 (greater than 0.994) were obtained. High extraction recoveries between 90.5 and 102.5 were obtained that show the sample matrix had little effect on the proposed method. This method also offered acceptable RSDs % (<4). The calibration curves were linear within the range of 0.3-100 and 0.6-100 μg L-1 for valsartan and atorvastatin, respectively
Template and target information: cardiovascular drugs, valsartan, atorvastatin
Author keywords: molecularly imprinted polymer, microextraction, sample preparation