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Abstract: It is difficult for most inorganic chemists to be aware of the availability of the many new techniques, described largely in analytical chemistry, environmental chemistry, and biomedical journals, which are increasingly of value in the separation and characterization of complexes of transition metals. Additionally, the design and use of supported transition metal complexes as sites for molecular recognition in the separation of biomolecules and organic materials has the potential to dominate multi-billion dollar industries in proteins and chiral drugs. This review serves as a roadmap for inorganic chemists to the recent chromatographic literature. The review covers advances in separation methods that involve transition metal chemistry which have occurred in the decade of 1992 through early 2003 with 360 references. The review is intended to assist readers in finding key papers that illustrate techniques of chromatography that might be applicable to purposes in the reader's laboratory. Covered topics include the standard separation of inorganic ions and metal complexes, capillary electrophoresis methods (CE, CZE, MEKC), electrochemical detection in flow methods by [Ru(bpy)(3)](3+/2+) cycling in response to analytes, separations of metal complexes of interest to environmental and biomedical disciplines via size exclusion chromatography (SEC), and detection methods with electrospray mass spectrometry (ESI-MS). Advances in affinity chromatography in the separation of peptide, proteins and biopolymers (IMAC) and of organic substrates (IMCOS) are discussed. Recent advances in understanding the mechanisms of chromatographic separations, and of the technique of polymer imprinting to produce selective recognition sites for metal ions and metal complexes are described. (C) 2003 Elsevier B.V. All rights reserved