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Reference type: Journal
Authors: Saad EM, El Gohary NA, Abdel-Halim M, Handoussa H, Mohamed El Nashar R, Mizaikoff B
Article Title: Molecularly imprinted polymers for selective extraction of rosmarinic acid from Rosmarinus officinalis L.
Publication date: 2021
Journal: Food Chemistry
Volume: 335
Article Number: 127644.
DOI: 10.1016/j.foodchem.2020.127644
Alternative URL: https://www.sciencedirect.com/science/article/pii/S0308814620315065

Abstract: This study provides a robust and reproducible approach for selective extraction of rosmarinic acid (RA) using molecularly imprinted polymers (MIPs). Computational modeling and UV spectroscopic analysis were performed to optimize MIP synthesis. Consequently, six different bulk and surface imprinted polymers were generated using RA as the template. Binding performance of the imprinted polymers was evaluated using static equilibrium and complementary dynamic rebinding experiments. Despite the high selectivity of thus generated surface imprinted polymers, the corresponding bulk polymers exhibited better binding performance when serving as sorbents during solid phase extraction (SPE). An optimized molecularly imprinted solid phase extraction (MISPE) protocol was developed in respect to loaded amount of RA, composition of the loading solution, washing solvent, and elution volume. Thereby, a remarkably selective extraction of RA from real-world Rosmarinus officinalis L. extract with a recovery rate and purity of 81.96 ± 6.33% and 80.59 ± 0.30%, respectively, was achieved
Template and target information: rosmarinic acid, RA
Author keywords: Computational studies, molecularly imprinted polymer, solid phase extraction, Rosmarinus officinalis, Phenolic acids, Rosmarinic acid


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