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Abstract: A novel method for the detection of antibiotics is developed by combining surface enhanced Raman scattering (SERS) with molecularly imprinted polymers (MIPs) on membrane materials. In this test, eggshell membrane (ESM) is selected as support material, which shows the advantages of low price, easy preparation and more functional groups comparing with other common synthetic membranes. Firstly, Ag nanoparticles with different morphologies are deposited on the surface of ESM by in-situ reduction, and then imprinted polymer is coated by precipitation polymerization to promote high specific sensitivity. The results present that the sensitivity of SERS imprinted membrane is mainly affected by Ag morphology. Under the optimal conditions, it presents a good linear relationship between SERS intensity and spiramycin (SP) concentration, and the coefficient of determination (R2) is 0.9981. It also exhibits the ability of selective detection and retrievability. It can be recycled at least 10 times. This method provides a cheap, stable and sensitive substrate, which broadens the research field of SERS detection of antibiotics
Template and target information: antibiotics, spiramycin, SP
Author keywords: Surface-enhanced Raman scattering, Molecularly imprinted polymers, selective detection, Eggshell membrane, Antibiotic detection