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Abstract: In this work, a new drug carrier, the hollow magnetic silybin liquid crystal molecular imprinted polymer (HMS@LC-MIP) was prepared through the reverse atom radical transfer polymerization(RATRP) method. In order to decrease the degree of cross-linker, the liquid crystal ingredient methylphenyl dicyclohexyl ethylene, a kind of physical cross-linker, being able to replace the chemical cross-linker partly, was introduced into the synthetic system. The characterizations of HMS@LC-MIPs were investigated by FT-IR, VSM, TEM and so on. A series of adsorption experiments showed the maximum adsorption capacity and the adsorption equilibrium time of HMS@LC-MIP were 18.53 mg g-1 and 180 min, respectively, and the relative selectivity factor β=2.06 implied HMS@LC-MIP had the high selectivity to the template. The in-vitro release experiments exhibited HMS@LC-MIP possessed the good responsiveness to pH values and the desirable slow release performance with 48 h of sustaining time. In short, the HMS@LC-MIP should be of a potential as drug sustained-release agent in the future
Template and target information: silybin
Author keywords: Silybin, Sustained-release carrier, Hollow, polymerization, liquid crystals