Alternatively for mipdatabase quick searches go here

Custom Search

Abstract: A novel molecularly imprinted electrochemiluminescene (ECL) sensor was fabricated for the detection of ethosuximide. The new Ru(pby)32+@N-GQDs (tris(2,2'-bipyridyl) ruthenium(II)@nitrogen doped graphene quantum dots) nanocomposite was synthesized by electrostatic interaction between Ru(pby)32+ and N-GQDs, which showed excellent and stable ECL properties. And then dopamine as functional monomer and ethosuximide as template molecule were co-polymerized by hydrogen bonding on the surface of Ru(pby)32+@N-GQDs/Nafion. After ethosuximide was extracted with H2SO4, the molecularly imprinted cavities in film were formed. When ethosuximide rebound onto imprinted cavities again, the ECL intensity of Ru(pby)32+@N-GQDs decreased. Based on this principle, the quantitative relationship between the concentration of ethosuximide (c) and the variation of ECL intensity (Δ IECL) was established. Namely the Δ IECL depended linearly on the log c in the range from 5.00 × 10-7 to 1.00 × 10-4 mol/L with a detection limit of 3.00 × 10-7 mol/L (S/N = 3), and the correlation coefficient was 0.9984. The proposed sensor was also applied in plasma and urine samples with recovery in range from 97.80% to 106.2% (RSD < 6.3%)
Template and target information: ethosuximide
Author keywords: Ru(pby)3^2+@N-GQDs, Electrochemiluminescene sensor, molecularly imprinted, Ethosuximide