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Abstract: Molecularly imprinted polymers (MIPs) are a fascinating technology for the sensitive and selective detection of target molecules. However, in most situations, the need for complicated and expensive analytical devices for reading the responses of MIPs greatly limits their applications. For exploring low-cost and easy-to-use applications of MIPs, herein we have developed a MIP-modified extended-gate type organic field-effect transistor (MIP-OFET). Taurine was selected as a demonstrative analyte due to its biological roles and utility as a nutrient. We explored the rational design of the novel MIP with the aid of density functional theory and wave function calculations and characterized the electrochemically synthesized MIP using differential pulse voltammetry and electrochemical impedance spectroscopy. The mechanism of taurine detection by the MIP-OFET can be explained by the changes in the surface potential of the MIP-functionalized extended-gate electrode accompanied with the capture of taurine. The detection limit of taurine in complete aqueous media was estimated to be 0.33 μM, which was lower or comparable to those calculated by high-performance liquid chromatography. Furthermore, taurine in a commercial drink without any extraction was also successfully detected using the fabricated MIP-OFET. This study would broaden the scope of the applications of MIP-OFETS as chemical sensors for on-site detection of various daily nutrients
Template and target information: taurine