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Reference type: Journal
Authors: Lu H, Cui HY, Duan DD, Li L, Ding YP
Article Title: A novel molecularly imprinted electrochemical sensor based on a nitrogen-doped graphene oxide quantum dot and molybdenum carbide nanocomposite for indometacin determination.
Publication date: 2021
Journal: Analyst
Volume: 146
Issue: (23)
Page numbers: 7178-7186.
DOI: 10.1039/D1AN01665B

Abstract: In this work, nitrogen-doped graphene oxide quantum dots (N-GOQDs) were embedded into Mo2C to prepare a nanocomposite with great electrical conductivity and a large specific surface area. We manufactured an innovative electrochemical sensor based on N-GOQDs-Mo2C and a molecularly imprinted polymer (MIP) for the highly sensitive detection of indometacin (IDMC). The MIP was synthesized by electropolymerization using acrylamide as the functional monomer and IDMC as the template molecule. N-GOQDs-Mo2C was organized by an elementary hydrothermal approach and characterized by SEM, TEM, XRD and FT-IR. In the first-rank experimental conditions, the MIP electrochemical sensor shows a wide linear range from 10-15 M to 10-5 M for IDMC detection and the detection limit is as low as 9.508 × 10-16 M. Additionally, the manufactured sensor shows great selectivity for indometacin, excellent repeatability and stableness. The sensor can be applied to the detection of indometacin in tablets and water samples with fulfilling consequence
Template and target information: indometacin, IDMC


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