Abstract: Incorporation of semiconductor nanoparticles into molecularly imprinted polymer provides a sensor material which can be easily shaped and with better selectivity because the bound template would quench the photoluminescence (PL) emission of quantum dots significantly. In this work, artificial receptors of various templates were synthesized with functional monomers such as methacrylic acid (MAA), semiconductor like CdSe/ZnS core-shell derivatized with 4-vinylpyridine and ethylene glycol dimethacrylic acid as the cross-linker. The quenching of photoluminescence emissions is presumably due to the fluorescence resonance energy transfer between quantum dots and template molecules. The photoluminescence emission is unaffected upon incubation of analyte with the blank control polymer. (C) 2003 Elsevier B.V. All rights reserved