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Book title: BioSensing, Theranostics, and Medical Devices: From Laboratory to Point-of-Care Testing
Editors: Borse V, Chandra P, Srivastava R
Publisher: Springer Singapore
City: Singapore
ISBN: 978-981-16-2782-8

Abstract: While developments in the field of molecular recognition elements enabled the progress in the creation of novel assays and sensors, and they also have an enormous potential for use in pharmaceutical industries and medicine. Currently, the most common recognition elements are antibodies, which are routinely used in affinity technologies and biomedicine due to their ability to specifically recognize a target molecule (the antigen). Nevertheless, antibody-based methods still face several obstacles, especially in their extremely high production costs that limit their widespread application as therapeutics. However, their limitations lead to the development of other, completely novel recognition components that are able to overcome the limitations of biological macromolecules. Among very promising areas appear to be aptamers, which are synthetic short single-stranded chains of nucleic acids that are able to bind to protein targets, and molecularly imprinted polymers that are synthetic polymers with recognition ability. In this chapter, a critical comparison of these recognition elements is offered, and their suitability for the pharmaceutical or medicine area is discussed in detail
Template and target information: review - MIPs as biorecognition elements
Author keywords: Molecularly imprinted electrochemical sensor, Growth hormone, Fe3O4 nanoparticles, aniline, Square wave voltammetry