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Reference type: Journal
Authors: Parmpi P, Kofinas P
Article Title: Biomimetic glucose recognition using molecularly imprinted polymer hydrogels.
Publication date: 2004
Journal: Biomaterials
Volume: 25
Issue: (10)
Page numbers: 1969-1973.
DOI: 10.1016/j.biomaterials.2003.08.025
Alternative URL: http://www.che.utexas.edu/research/biomat/PDFReprints/Biomaterials_25_1969-1973(2004).pdf

Abstract: Non-covalent molecular imprinting of poly(allylamine hydrochloride) (PAA - HCl) with D-glucose 6-phosphate monobarium salt (GPS-Ba) produced molecularly imprinted polymer hydrogels (MIP) having an affinity to glucose over fructose. The hydrogels were formed by ionic association of the template molecule, GPS-Ba, to the polymer, prior to covalent crosslinking using epichlorohydrin (EPI). The template was removed by an aqueous base wash. Batch equilibration studies using different MIP hydrogels and non-molecularly imprinted polymers (NIPs) were performed in aqueous and buffered media to determine the binding capacities and isomeric selectivities with respect to the sugars, glucose and fructose. MIP glucose hydrogels exhibited binding capacities in excess of 0.6 g of glucose per g of dry gel in a 100% D1 H2O glucose solution, and in a 50-50% glucose-fructose solution mixture. Equilibrium binding capacities of fructose were lower than those observed with respect to glucose, indicating an isomeric preference for the binding of glucose over fructose. These hydrogels demonstrated a remarkable degree of biomimetic sugar recognition to specifically and selectively bind glucose in their swollen state in environments mimicking physiological conditions. (C) 2003 Elsevier Ltd. All rights reserved
Template and target information: D-glucose 6-phosphate monobarium salt, GPS-Ba, glucose

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