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Abstract: Molecularly imprinted polymer for the selective adsorption of oxazepam was synthesized using precipitation polymerization in the presence of oxazepam as a template, ethylene glycol dimethacrylate as a crosslinking agent, methacrylic acid as a functional monomer and 2,2-azobisisobutyronitrile as an initiator. The polymer was characterized by scanning electron microscopy, Fourier-transform infrared spectroscopy and thermogravimetric analysis. The obtained molecular imprinting polymer showed high affinity to template molecule and was used as a selective sorbent for selective extraction of oxazepam from human urine and plasma samples. Good linearity was obtained for the analyte in the range of 2.0-600 μg/L with relative standard deviation ≤ 4.0%. Under optimal conditions, maximum adsorption capacity obtained was 136 mg/g. The detection limit of the proposed procedure was 0.5 μg/L. Finally, this method was applied to the determination of oxazepam in plasma and urine samples and satisfactory results were achieved
Template and target information: oxazepam
Author keywords: molecularly imprinted polymer, oxazepam, human urine and plasma, high performance liquid chromatography