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Abstract: Molecularly imprinted polymers (MIPs) constitute a perfect example of bioinspired functional materials. These tailor-made recognition materials that can mimic biological receptors [1]. If used as the recognition units for chemosensor fabrication, they outperform natural receptors with their durability, chemical stability, and low production costs. Novel techniques of MIP deposition as a thin film, surface development, and introduction of additional properties are very much demanded in terms of selective and sensitive chemosensors fabrication [2]. For that purpose, novel hierarchically templated polythiophene film were synthetized [3-4]. The structure of the deposited film was controlled in three size ranges. Application of 500 nm in dimeter SiO2 particles colloidal crystal as the sacrificial mold resulted in deposition of macroporous inverse opal polythiophene film. Optimized electropolymerization procedure enabled to grow polymer from the electrode surface and precisely control thickness of the deposited films. Electropolymerization was stopped in such moment that all pores were fully opened. Moreover, template protein immobilization on SiO2 colloidal crystal surface prior the electropolymerization enabled location of imprinted molecular cavities only on the pores inner surface. Semi-covalent imprinting ensured location of functional monomers solely in imprinted cavities in positions complementary to recognition sites of the template protein molecules. Such precise control over deposited MIP film structure resulted in superior analytical parameters of the devised MIP-chemosensor and, thus, it enabled target protein (i.e., HSA, hCG, or FSH) selective determination in fM concentration range. In another approach, redox-active conductive MIP film was deposited. For that purpose, ferrocene moieties were immobilized inside of the p-synephrine imprinted polythiophene film. This film acted as a self-reporting recognition material on the electrode surface. Thus, it enabled voltametric determination of electro-inactive analyte, namely p-synephrine, without addition of any redox probe to the sample solution in nM concentration range.
Template and target information: protein, HSA, hCG, FSH, p-synephrine
Author keywords: Molecularly imprinted polymers, Conductive polymers, Selective chemosensors