Abstract: The specific binding of templated macroporous polymers is of much interest for separations science and enzyme-like catalysis. While covalently bound imprints work best, non-covalently imprinted polymers are attractive because of the easy removal of the imprint and rapid rebinding. We explore hydrogen bonding, electrostatic interactions, and minor metal-ligand interactions in new noncovalently imprinted polymers designed for the specific recognition of macrocyclic metal complexes. The imprinting of all N,N',N'',N'''- tetra(2-carbamoylethyl)cyclam-nickel(II) salts involve multiple hydrogen bonding interactions when combined during copolymerization with the functional monomer acrylamide or with the crosslinking monomer N,N'-ethylenebisacrylamide. Parallel experiments using the vinylsulfonate salt of the same macrocyclic complex add electrostatic interactions, and use of good coordinating groups as functional polymers (e.g. vinyl pyridines) adds the minor ligand component. Selectivity is being explored for a range of metal ions. The polymers are characterized by the extent of rebinding, selectivity, and morphological determinations