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Reference type: Journal
Authors: Devanathan S, Salamon Z, Nagar A, Narang S, Schleich D, Darman P, Hruby V, Tollin G
Article Title: Subpicomolar sensing of δ -opioid receptor ligands by molecular-imprinted polymers using plasmon-waveguide resonance spectroscopy.
Publication date: 2005
Journal: Analytical Chemistry
Volume: 77
Issue: (8)
Page numbers: 2569-2574.
DOI: 10.1021/ac048476e

Abstract: Here we report, for the first time, the formation of a biomimetic covalently imprinted polymeric sensor for a target ligand, the delta-opioid G-protein coupled receptor agonist DPDPE, which reproducibly exhibits subpicomolar binding affinity in an aqueous environment. In addition to having a well-defined and homogeneous binding site, the imprinted polymer template is quite stable to storage in both the dry and wet states and has at least 6 orders of magnitude higher affinities than exhibited by similar peptide-based molecular- imprinted polymers (MIPs) thus far. A highly sensitive optical detection methodology, plasmon-waveguide resonance spectroscopy, was employed, capable of measuring binding in real time and discriminating between ligand molecules, without requiring labeling protocols (fluorophores or radioisotopes). The DPDPE-imprinted polymer showed a broad structure-activity relationship profile, not unlike that found for protein receptors. Such sensitivity and robustness of MIPs suggests potential applications ranging from bio-warfare agent detection to pharmaceutical screening
Template and target information: peptide, δ -opioid G-protein coupled receptor agonist, DPDPE, Tyr-D-Pen-Gly-Phe-D-Pen


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