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Abstract: In the presence of template molecules of N-Boc-L-Tryptophan (Trp) and N-Boc-L-Tyramine (Tyr), two kinds of molecularly imprinted polymers (MIPs) were synthesized by photo induced and thermal induced polymerization, respectively. High pressure liquid chromatography analyses using MIPs as the stationary phase showed that both MIPs could specifically recognize the corresponding imprinted molecules from the racemic mixtures of amino acid derivatives. The separation factors of N-Boc-L-Trp and N-Boc-L-Tyr on the corresponding MIPs were 2.318 and 1.373, respectively. The surface structure observation of MIPs by Scanning Electronic Microscopy showed that both MIPs and blank polymers polymerized by photo and thermal inducement were porous granules with different kinds of pores. From pore structure analyses, some differences between MIPs and blank polymers in pore-structures were found, and the difference in pore-diameter between MIPs and blank polymers by photo-induced polymerization was more obvious than that of the thermal induced polymers. When the imprinted molecules were removed from MIPs by elution, the structures of pores of various sizes in the MIPs were all markedly changed,showing that the imprinted molecules could be adsorbed by MIPs in any kinds of pores. All these results indicated that the pore-structure of MIPs played very important roles in the process of molecular recognition of the imprinted molecules
Template and target information: N-Boc-L-Tryptophan, Trp, N-Boc-L-Tyramine, Tyr
Author keywords: Molecularly imprinted polymers, photo induced polymerization, thermal induced polymerization, pore structure