Authors: Manesiotis P
, Hall AJ
, Courtois J
, Irgum K
, Sellergren B
An artificial riboflavin receptor prepared by a template analogue imprinting strategy.
Publication date: 2005
Journal: Angewandte Chemie International Edition
Abstract: Cheers! Specificity for riboflavin in water-rich media with an affinity on the order found for the corresponding biological receptor, riboflavin binding protein, is shown by a receptor containing a complementary hydrogen bonding array (see picture). Microcalorimetry performed at low receptor concentrations in a solution mimicking an alcoholic beverage indicated the presence of a small but uniform population of high-affinity sites (K > 10^6 m-1).
Template and target information: riboflavin
Author keywords: hydrogen bonds, imprinting, molecular recognition, receptors, riboflavin
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