Authors: Burkett CM
, Edmiston PL
Generating selective binding matrixes for TNT using molecular imprinting: The effect of template and processing conditions.
Publication date: 2005
Journal: Abstracts of Papers of the American Chemical Society
Alternative URL: http://www.chemistry.org/portal/resources/ACS/Subportals/analytical/anyl_spring05.pdf
Abstract: Sol-gel xerogels were molecularly imprinted for TNT using a variety of covalently bound templates which were chemically removed to generate selective binding pockets. The sol-gel composition and processing conditions (solvent and drying temperature) were altered to optimize selectivity and affinity for TNT. An equilibrium binding assay was used to measure the affinity of the imprinted sol-gels for TNT and structural analogues compared to non-imprinted controls. Binding isotherms were measured to determine the binding affinity and heterogeneity of the imprinted sites. The ability of the imprinted sol-gel materials to selectively bind TNT is being applied to generate solid phase extraction matrixes and sensor recognition elements.
Template and target information: 2,4,6-trinitrotoluene, TNT
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