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Reference type: Journal
Authors: Greene NT, Lee JD, Shimizu KD, Hong JI
Article Title: Molecular imprinted array for carbohydrate discrimination.
Publication date: 2005
Journal: Abstracts of Papers of the American Chemical Society
Volume: 229
Issue: (ANYL)
Page numbers: 392.
Alternative URL: http://www.chemistry.org/portal/resources/ACS/Subportals/analytical/anyl_spring05.pdf

Abstract: Molecular imprinting has become a desirable method in which to quickly produce large quantities of bulk material with causal properties of labor intensive synthetic scaffolds. These molecular imprinted polymers (MIPs) which possess high thresholds both thermally and chemically pose a more robust and stable comparison than their biomimetic counterparts, enzymes and antibodies. In this account we present a porphyrin-based sensor array format that is capable of discriminating a wide range of carbohydrate derivatives (monosaccharide, disaccharides, and furanosides) while still possessing sufficient selectivity to accurately classify common anomeric and epimeric sugars (n-octyl-α-D-glucopyranoside, n-octyl-β-D-glucopyranoside, and n-octyl-β-D-galactopyranoside). The sensor construction alone offers carbohydrate recognition without the inclusion of metal or boronate interactions, while binding affinities, utilizing urea appendages, remain elevated. In addition, through the incorporation of a two dye indicator displacement assay the dimensionality of the array was extended to ten variables, as a result of each indicators individual response to the array.


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