MIPdatabase
Authors: Li P, Xi RB, Zhan SZ, Lin BP, Yuan CW
Publication date: 2000
Chapter title: Resolution of amino acid derivative on molecularly imprinted polymer.
Page numbers: 419-420.
Book title: IEEE-EMBS Asia Pacific Conference on Biomedical Engineering - Proceedings, Pts 1 & 2
Editors: Zheng XX, He B, Zhang YT
Publisher: World Publishing Corporation
City: Beijing
ISBN: 7-5062-4828-X
Series title: IEEE Conference Proceedings
Abstract: alpha -methylacrylic acid and 1,4-butanediyl diacrylate were copolymerised in the presence of the template, L-phenylalanine ethyl ester (L-PHET). The template was extracted from the polymer, leaving specific recognition sites complementary to the template. By high performance liquid chromatography (HPLC), the polymers exhibited good enantiomeric resolution of the L, D-PHET. The method involves the formation of non-covalent interaction between the print molecule and the functional monomer prior to the initiation of polymerization. These interactions are subsequently responsible for the recognition of molecules by the polymer. The results indicated that the optimum ratio of functional monomer to print molecule was 4:1; the enantioseparation factor is 1.69. The recognition mechanism was investigated also
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