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Abstract: A barbituric acid sensor based on molecularly imprinted polymer-modified hanging mercury drop electrode is reported for sensitive and selective analysis in aqueous and blood plasma samples. It was developed by coating directly the barbituric acid-imprinted polymer, which is prepared from melamine and chloranil, onto the surface of a hanging mercury drop electrode under charge-transfer interaction at +0.3 V (vs. Ag/AgCl) in Model 303A electrode system connected with a polarographic analyzer/stripping voltammeter (PAR Model 264A). The binding event of barbituric acid was detected in the imprinted polymer layer through differential pulse, cathodic stripping voltammetric (DPCSV) signal at optimized operational conditions [accumulation potential +0.3 V (vs. Ag/AgCl), accumulation time 120 s, pH 7.0 (without supporting electrolyte), scan rate 10 mV s(-1), pulse amplitude 25 mV]. The limit of detection for barbituric acid was found to be 0.54 ppm (RSD = 3.7%, S/N= 3). The detection was feasible without any problem of matrix effect or cross reactivity in the linearity range of concentration varying from 0.50 to 125.00 ppm of barbituric acid
Template and target information: barbituric acid
Author keywords: Barbituric acid sensor, Molecularly imprinted polymer-modified hanging mercury drop electrode, Differential pulse cathodic stripping voltammetry, Blood plasma samples