MIPs logo MIPdatabase      MIP2024 Conference banner, website is now open, register on site for important updates   
Custom Search
Reference type: Conference Proceeding
Authors: Uragami T, Jige M, Miyata T
Publication date: 2002
Article title: Synthesis of glycoprotein-sensitive hydrogels with multi-ligands by biomolecular imprinting and their glycoprotein-responsiveness.
Page numbers: 1841
Alternative URL: http://www.jstage.jst.go.jp/article/spsjppj/51/0/51_1841/_article

Proceedings title: Polymer Preprints, Japan
Volume number: 51

Abstract: a-Fetoprotein (AFP) which is a glycoprotein is widely used as a diagnostic tumor-specific marker. In this study, novel stimuli-responsive hydrogels that underwent swelling changes in response to AFP were prepared by biomolecular imprinting using lectin and antibody as ligands for AFP. In the biomolecular imprinting, vinyl-antibody was copolymerized with acrylamide and methylenebisacrylamide with forming a lectin-AFP-antibody complex in the presence of polymerized lectin, and the AFP as a print biomolecule was removed from the resultant hydrogel. The AFP-imprinted hydrogel was shrunken in the phosphate buffer solution containing AFP, but nonimprinted hydrogel was a little swollen. The AFP-responsive shrinking of the AFP-imprinted hydrogel is due to the fact that the formation of a lectin-AFP-antibody complex in the hydrogel results in increasing cross-linking density.


  mipdatabase.com logo special offer joke shirt  Lab Chick Periodic table shirt  HE-MAN polymer chemistry shirt






 

Join the Society for Molecular Imprinting
Logo of the Society for Molecular Imprinting

New items RSS feed
new items RSS feed  View latest updates

Sign-up for e-mail updates:
Choose between receiving an occasional newsletter or more frequent e-mail alerts.
Click here to go to the sign-up page.


Is your name elemental or peptidic? Enter your name and find out by clicking either of the buttons below!
Other products you may like:
view listings for MIP books on eBay:



Mickey Mouse 90th Anniversary banner