Abstract: Using acrylamide and methylacrylic acid as functional monomers, human hemoglobin molecular-imprinting-polymers (HHb-MIPs) were successfully prepared. The studies showed that the specific molecular recognition properties of HHb-MIPs were related to both the interactions between the functional groups of polymers and imprinted protein, and geometric complementation of the cavities in the polymers. Further studies showed that the content of methyacrylic acid in the polymers could affect the specific binding properties of MIPs. The supplementation of methylacrylic acid can increase the specific adsorption capacity of the HHb-MIPs on the one hand, but decrease the elution capacity on the other hand
Template and target information: protein, human hemoglobin, HHb
Author keywords: acrylamide, Human hemoglobin, Methylacrylic acid, molecular imprinting polymers, molecular recognition