MIPdatabase
Authors: Caro E, Marce RM, Cormack PAG, Sherrington DC, Borrull F
Article Title: Synthesis and application of an oxytetracycline imprinted polymer for the solid-phase extraction of tetracycline antibiotics.
Publication date: 2005
Journal: Analytica Chimica Acta
Volume: 552
Issue: (1-2)
Page numbers: 81-86.
DOI: 10.1016/j.aca.2005.07.047
Alternative URL: http://www.sciencedirect.com/science/article/B6TF4-4H21NDB-2/2/80b0eea81f42a96a8cf8ec4e738ccbe2
Abstract: Two molecularly imprinted polymers (MIPs) were synthesised using tetracycline and oxytetracycline antibiotics as template molecules in non-covalent molecular imprinting procedures. After a chromatographic evaluation, the performance of the MIPs as selective SPE sorbents was evaluated. In this study, it was demonstrated that after a clean-up step to disrupt the non-specific interactions between the MIPs and the compounds retained on them, the polymers showed cross-reactivity for certain other tetracycline analytes. The feasibility of the MIP to selectively extract tetracycline antibiotics in pig kidney tissue extract was demonstrated with the oxytetracycline MIP which gave rise to the best MISPE results when it was applied. Good recoveries were obtained when oxytetracycline and tetracycline were selectively extracted from 25 ml of pig kidney tissue extract
Template and target information: tetracycline, oxytetracycline
Author keywords: column liquid chromatography, Solid-phase extraction, molecularly imprinted polymer, Tetracycline antibiotics, Tissue samples
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