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Reference type: Journal
Authors: Hsieh RY, Tsai HA, Syu MJ
Article Title: Designing a molecularly imprinted polymer as an artificial receptor for the specific recognition of creatinine in serums.
Publication date: 2006
Journal: Biomaterials
Volume: 27
Issue: (9)
Page numbers: 2083-2089.
DOI: 10.1016/j.biomaterials.2005.09.024
Alternative URL: http://www.sciencedirect.com/science/article/B6TWB-4HBSH0Y-1/2/40c5d50e9f6c6108bdbc7cf0bf17c13c

Abstract: In this study, molecularly imprinted polymers (MIP) synthesized from two different functional monomers, β-cyclodextrin (β-CD) and 4-vinylpyridine (4-Vpy), were prepared. The crosslinkers used for these two monomers were epichlorohydrin (EPI) and divinylbenzene (DVB), respectively. It was attempted to adsorb the target molecule, creatinine, from its mixture solutions. A proper molar ratio of monomer/crosslinker for the preparation of the imprinted poly(β-CD) was 1:10. Between both polymers mentioned above, the affinity of the imprinted poly(4-Vpy-co-DVB) towards creatinine was comparably superior. The imprinted poly(4-Vpy-co-DVB) for creatinine could reach a specific binding ratio of 3.11. The imprinted poly(4-Vpy-co-DVB) was further utilized to bind creatinine from human serum samples. The binding capacity of the imprinted poly(4-Vpy-co-DVB) for creatinine from the serum samples was plotted against the creatinine concentration. From the correlation, the feasibility of the imprinted poly(4-Vpy-co-DVB) thus prepared for the target analyte, creatinine, was experimentally confirmed
Template and target information: creatinine
Author keywords: β-cyclodextrin, 4-vinylpyridine, creatinine, Imprinting factor, serum


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