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Reference type: Journal
Authors: Li Y, Yang HH, You QH, Zhuang ZX, Wang XR
Article Title: Protein recognition via surface molecularly imprinted polymer nanowires.
Publication date: 2006
Journal: Analytical Chemistry
Volume: 78
Issue: (1)
Page numbers: 317-320.
DOI: 10.1021/ac050802i
Alternative URL: http://www.aseanbiotechnology.info/Abstract/21021150.pdf

Abstract: In this paper, we present a technique for the preparation of polymer nanowires with the protein molecule imprinted and binding sites at surface. These surface imprinting nanowires exhibit highly selective recognition for a variety of template proteins, including albumin, hemoglobin, and cytochrome c. This recognition may be through a multistep adsorption, with the specificity conferred by hydrogen bonding and shape selectivity. Due to the protein imprinted sites are located at, or close to, the surface; these imprinted nanowires have a good site accessibility toward the target protein molecules. Furthermore, the large surface area of the nanowires results in large protein molecule binding capacity of the imprinted nanowires.
Template and target information: protein, albumin, hemoglobin, cytochrome c


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