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Reference type: Journal
Authors: Miyata T, Jige M, Nakaminami T, Uragami T
Article Title: Tumor marker-responsive behavior of gels prepared by biomolecular imprinting.
Publication date: 2006
Journal: Proceedings of the National Academy of Sciences of the United States of America
Volume: 103
Issue: (5)
Page numbers: 1190-1193.
DOI: 10.1073/pnas.0506786103
Alternative URL: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1360525&tool=pmcentrez

Abstract: We report dynamic glycoprotein recognition of gels prepared by biomolecular imprinting using lectin and antibody molecules as ligands for tumor-specific marker glycoproteins. The glycoprotein-imprinted gels prepared with minute amounts of cross-linkers could dynamically recognize tumor-specific marker glycoproteins by lectin and antibody ligands and induce volume changes according to the glycoprotein concentration. The glycoprotein-imprinted gel shrank in response to a target glycoprotein but nonimprinted gel swelled a little. The glycoprotein-responsive shrinking of the imprinted gel was caused by formation of lectin-glycoprotein-antibody complexes that acted as reversible cross-linking points. Glycoprotein-imprinted gels only shrank when both lectin and antibody in the gels simultaneously recognized the saccharide and peptide chains of the target glycoprotein. As shrinking behavior of biomolecularly imprinted gels in response to glycoproteins enables the accurate detection and recognition of tumor-specific marker glycoproteins, they have many potential applications as smart devices in sensing systems and for molecular diagnostics
Template and target information: glycoprotein
Author keywords: gel, tumor-specific marker, stimuli-responsive gel, molecular recognition


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