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Reference type: Conference Proceeding
Authors: Wu CT, Ho KC
Publication date: 2005
Article title: Amperometric (+)-catechin sensing using a molecularly imprinted polymer-modified electrode.
Page numbers: 1471

Abstract: Molecular imprinting technique provides a new technology to synthesize an artificial antibody for biomolecular assays in human body. Molecular imprinted polymers (MIPs), which incorporating factitious templates and are used for the molecular recognition of target molecules based on the shape and structure of functional monomer, have been rapidly developed and widely researched in the past decade [1]. Moreover, synthesizing a bulk MIP from a monomer then grinds it into small particles for adsorption studies has become the standard procedure in MIPs synthesis and subsequent molecular sensing. We have developed a modified electrode by utilizing the conducting polyaniline to synthesize the MIPs that can sense an anti-oxidant based on the electrochemical techniques. This is a simple and reliable method in detecting various biomolecules with required sensitivity and selectivity. (+)-Catechin, a type of polyphenols which are natural anti-oxidant widely found in plants. A research reveals that human ingest polyphenols can prevent cancer [2]. In order to sense accurate amount of catechins, time-consuming high performance liquid chromatography was usually employed [3-4]. On the other hand, by combing the selectivity of the MIPs with the rapid response of the electrochemical sensing, one may establish a reliable, selective sensing protocol. In this study, we focus on the use of a polyaniline (PAn)-modified optically transparent indium tin oxide (ITO) electrode for sensing (+)-catechin. Preliminary data show that there is a redox peak at about 0.35 V (vs. Ag/AgCl/Sat'd KCl) (Fig. 1). Thus, by applying the above-mentioned voltage, one can measure the response current for (+)-catechin detection with high sensitivity. The detection current responds linearly to the bulk concentration of (+)-catechin. By using a molecularly imprinted polymer-modified electrode, a rapid biomolecular sensing of (+)-catechin has been demonstrated
Template and target information: (+)-catechin


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