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Abstract: Molecular imprinting is a technique for the generation of highly specific binding sites within a synthetic polymer. These sites are complementary in geometry and functionality to the analyte molecules. Molecular imprinting has proven to be a very effective method that creates three-dimensional binding sites in the case of polymers. In the present study molecular imprinting was achieved by synthetic polymers, which were first tethered covalently to the nerve agent (NA) analog. The main advantage of covalent imprinting is that the interaction between the template and functional monomer is much less affected by solvent polarity and temperature during the imprinting process. Furthermore, the functional groups are only situated inside the cavities and not statistically distributed all over the polymer matrix as it is usually the case with noncovalent imprinting in which a large excess of polymerizable binding sites have to be used. In the present study, we have synthesized three polymers, one of them was grafted to the analyte of interest and the other two were synthesized to compare and study selectivity and the control of the analyte. Pinacolyl methylphosphonate (PMP) was chosen as the analyte for the present case. PMP is a degradation product from the hydrolysis of nerve agent Soman.
Template and target information: pinacolyl methylphosphonate, PMP, nerve agent analog, Soman