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Reference type: Journal
Authors: Gomy C, Schmitzer AR
Article Title: Rational design of new polymerizable oxyanion receptors.
Publication date: 2006
Journal: Journal of Organic Chemistry
Volume: 71
Issue: (8)
Page numbers: 3121-3125.
DOI: 10.1021/jo060088k

Abstract: We report the synthesis of a library of new polymerizable functional monomers designed for complexing with the oxyanionic moiety of the chemotherapeutic drug methotrexate. The 1H NMR and ITC binding studies allowed for the selection of receptors possessing the best association parameters. Subsequently, the design of a broad library of polymerizable moiety-specific binding monomers for the imprinting of dicarboxylate containing drugs was accomplished. Di(ureidoehylenemethacrylate)stilbene possesses the highest association properties and shows potential to act as a monomer in the molecularly imprinting technique to obtain photoswitchable cavities.
Template and target information: methotrexate, N-Z-L-glutamic acid


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