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Abstract: Stimuli-responsive gels that exhibit swelling-shrinking behavior by changing external conditions such as temperature and pH have many potential applications as smart materials for sensors, DDS, etc. We have used molecular imprinting to prepare molecule-responsive gels that undergo volume changes in response to a target molecule. This paper focuses on the effect of structures of molecularly imprinted gels on their molecule-responsive behavior. Bisphenol A (BPA)-imprinted gels, which were prepared by using cyclodextrin (CD) as a ligand for BPA, shrank more remarkably in water containing BPA than nonimprinted gel. Furthermore, introducing a large amount of CD into the BPA-imprinted gels enhanced their BPA-responsive behavior. On the other hand, glycoprotein- imprinted gels prepared using lectin and antibody as ligands shrank in response to a target glycoprotein (AFP). Molecule-responsive behavior of the BPA-imprinted gel and the AFP-imprinted gel is based on the formation of the CD-BPA-CD complex and the lectin-AFP-antibody complex that act as cross-linking points. We will reveal that structural design of molecularly imprinted gels can improve their molecule-responsive behavior
Template and target information: bisphenol A, BPA, glycoprotein, AFP
Author keywords: antibody, bisphenol A, cyclodextrin, glycoprotein, lectin, molecular imprinting, stimuli-responsive gel